PEPTIDES

Peptides are biological molecules found in all living organisms. They play a key role in all manner of biological activity.

Recent research indicates that some types of peptides could have a beneficial role in slowing down the aging process, reducing inflammation, stimulating arousal, and destroying microbes.

People may confuse peptides with proteins. Both proteins and peptides are made up of amino acids, but peptides contain far fewer amino acids than proteins. Like proteins, peptides are naturally present in foods.  This helps to target the peptide action.

Sermorelin  |  CJC1295  |  Ipamorelin  |  GHRP 2  |  GHRP 6

Increase Human Growth Hormone (HGH) Without HGH Sermorelin and CJC1295 are “growth hormone-releasing hormones” (GHRH), meaning it stimulates the pituitary gland to naturally produce increased amounts of human growth hormone.

Sermorelin and CJC1295 are not the same as HGH, it is a growth hormone secretagogue, which means that it stimulates the pituitary gland to produce and secrete HGH. Sermorelin and CJC1295 can be injected with a small insulin needle or alternatively, there is a sublingual version of Sermorelin that has shown comparable results.

Benefits of HGH Stimulating Peptide Therapy

Increased levels of growth hormone are reported to assist in:

  • Stronger bone density
  • Increased muscle mass
  • Increased protein synthesis
  • Stimulation of the growth of all internal organs, excluding the brain
  • Playing a role in energy balance
  • Energy formation from fat breakdown
  • Stimulating the immune system
  • Improve Sleep and Wellbeing
  • Lower atherosclerotic plaque production, reducing the risk for developing:
    • Hypertension
    • Stroke/Aneurysm
    • Myocardial Infarction – “Heart Attack”
    • Heart Failure
    • Kidney Failure
    • Vision changes/loss

Sermorelin Therapy:

Increase Human Growth Hormone (HGH) Without HGH

Sermorelin is a “growth hormone-releasing hormone” (GHRH), meaning it stimulates the pituitary gland to naturally produce increased amounts of human growth hormone. Sermorelin is a form of GRF, a growth hormone-releasing factor, which contains only the first 29 amino acids. GHRF is produced by neurosecretory neurons in the brain contains 44 amino acids. 

When the structure of GHRF was first described by Nobel Laureates R. Guilleman and A. Shalley in the 1970s, one of their students, William Wehrenberg, sought to determine which part of the HGH molecule was essential for its pituitary stimulating action. By eliminating individual amino acids and then testing the remaining peptide, he found that only the first 29 amino acids are responsible for stimulating pituitary production and secretion of HGH.

Under physiological conditions, HGH is released from the pituitary gland in episodes that cause levels to increase and decrease many times throughout the day.  Under such conditions, tachyphylaxis or down-regulation does not occur since the tissue’s receptors get time to “rest” between each stimulatory event. 

In contrast to HGH, there is no loss of potency with Sermorelin because its action on the pituitary gland is modulated by feedback through somatostatin. This causes HGH to be released from the pituitary in episodes rather than in “square wave” pharmacological presentation as occurs upon injection of the gene recombinant HGH product. In addition, the pituitary gland up-regulates to stimulation by Sermorelin causing the gland to rejuvenate.

Sermorelin is an alternative to HGH that can legally be prescribed “off label”. 

Sermorelin, which stimulates the production of the body’s own HGH has recently become available for use to address adult hormone deficiency. Sermorelin is a truncated analog of growth hormone-releasing hormone or factor (GRF 1-44) that is naturally produced by the brain to stimulate pituitary production and secretion of HGH. 

Sermorelin not only provides the benefits of HGH on body composition, but it also helps sustain pituitary health and opposes loss of activity of the endocrine system that normally occurs during aging. Since estrogen and adiposity negatively affect growth hormone action on the liver to produce IGF-1, higher doses of Sermorelin are recommended for women and men with high body mass indexes (BMIs).

Sermorelin is a biological active analog of growth hormone-releasing hormone (GHRH) that is produced by the human brain to stimulate the production and release of growth hormone by the pituitary gland. During youth, ample amounts of GHRH are produced so that the pituitary is able to provide the body with sufficient growth hormone to sustain normal aspects of form and function. GHRH declines with age causing reduced production and secretion of pituitary HGH and thereby increasing the sequelae of growth hormone insufficiency. Unlike HGH, Sermorelin affects a more primary source of failure in the GH neuroendocrine axis, has more physiological activity, a better safety profile, and its use for adult hormone deficiency is not prohibited (as is HGH). Thus, Sermorelin should be considered a valuable alternative to HGH.

 

    Benefits of Sermorelin:

    Increased levels of growth hormone are reported to assist in:

    • Increased calcium retention
    • Stronger bone density
    • Increased muscle mass
    • Increased protein synthesis
    • Stimulation of the growth of all internal organs, excluding the brain
    • Promotion of lipolysis
    • Playing a role in energy homeostasis
    • Reducing liver uptake of glucose, promoting gluconeogenesis (formation of glucose from non-carbohydrate source, i.e. energy formation from fat breakdown
    • Stimulating the immune system
    • Increased stature in children with diagnosed short stature
    • Treatment of the prevention of HIV-induced cachexia

      Reduced Risk:

      • Hypertension
      • Stroke/Aneurysm
      • Myocardial Infarction – “Heart Attack”
      • Heart Failure
      • Kidney Failure
      • Vision changes/loss
      • Promoting the breakdown of body fat while promoting lean muscle mass

      Peptides Are Developed to Have Very Specific Action, Resulting in Effectiveness and Safety.

      PT141 (Bremelanotide)

      According to a scientific study that has been performed on animal test subjects, PT-141 (Bremelanotide) works by activating receptors in the central nervous system.  Brain transmissions are sent to the parts of the central nervous system tied to blood flow.

      PT141 in clinical trials for female sexual arousal but in the process have been shown to be quite effective for enhanced male sexual arousal in addition to erection quality and sexual satisfaction.

      PT 141 (Bremelanotide) – central melanocortin receptor agonis

      Dissolve one pellet under the tongue daily in the AM.

      PT-141 was developed from the peptide, Melanotan 2, which is a synthetically produced variant of a peptide hormone naturally produced in the body that stimulates melanogenesis that is known as alpha- Melanocyte stimulating hormone. PT-141 has been shown in studies to provide libido-enhancing effects by activating the melanocortin receptors MC1R and MC4R, without tanning the skin. PT-141 is a potential remedy for the treatment of female sexual dysfunction and male erectile dysfunction. Studies have shown that PT-141 does not act on the vascular system but may increase sexual desire through the nervous system.

      Peptide Therapy and Male Sexual Function:

      AOD 9604

      Last 15 aminos in GH. Mimics the effect of HGH on lipid metabolism, without having growth-promoting or pre-diabetic effects. Fragment of GH specifically for lipolysis

      Apply 1ml Cream AM and PM for fat loss x 7 weeks.                                        

      Length of treatment varies – 6 weeks, 3 months, up to 6 months. –  No allergenic reactions 

      *300 mcg Sub Q for fat loss AM and PM x 7 weeks.                                        

      Length of treatment varies – 6 weeks, 3 months, up to 6 months. –  No allergenic reactions

      FAT LOSS:  AOD 9604 is a modified form of amino acids 176-191 of the GH polypeptide. Investigators at Monash University discovered that the fat-reducing effects of GH appear to be controlled by a small region near one end of the GH molecule. This region, which consists of amino acids 176-191, is less than 10% of the total size of the GH molecule and appears to have no effect on growth or insulin resistance. This hypothesis was proven in animals to a tremendous degree with specimens losing a significant amount of fat mass. However, in phase three clinical trials the peptide didn’t mean its confidence interval. Instead, it is now being studied for its effects on bone and cartilage. AOD 9604 possesses many other regenerative properties associated with growth hormones. Currently, trials are underway to show the application of AOD 9604 in osteoarthritis, Hypercholesterolemia, bone and cartilage repair. AOD 9604 has an excellent safety profile, recently obtaining Human GRAS status in the USA.

      BPC- 157 ORAL

      (Body Protection Compound) Isolated from human gastric juice

      Oral – 500mcg (capsule) once daily x 30 days                                                               

      BPC-157 is a penta-deca-peptide made up of 15 amino acids. It is a partial sequence of the body protection compound (BPC) derived from human gastric juice. Experiments have shown that it heightens the healing of many different types of tissues including, tendons, muscles, nervous system, and is superior at healing damaged ligaments. Patients who suffer from discomfort due to sprains, tears, and tissue damage may benefit from treatment with this peptide as it can increase blood flow back to the injured sites. BPC-157 may protect organs, prevent stomach ulcers, heal leaky gut, and heal skin burns.

       

      • Significant anti-inflammatory modulating effects
        • Promotes tissue healing through signaling pathways
        • No primary effect, all about signaling

      Dihexa Acetate

      Take one capsule by mouth daily.

      DIHEXA is a peptide variant derived from angiotensin IV. Clinical studies suggest that DIHEXA improves cognitive function as shown in animal models of diseases such as Alzheimer’s. Angiotensin IV is a derivative of the vasoconstrictor angiotensin II which has been shown in animal studies to enhance acquisition, consolidation, and recall of learning and memory when administered centrally or peripherally. In an assay of neurotrophic activity, DIHEXA was found to be seven orders of magnitude more potent than brain-derived neurotrophic factor and is thought may be able to help in the repair of the brain and nerves in neurological disease.

      CJC 1295 and Ipamorelin

      Growth Hormone Releasing Hormone

      *outperforms Sermorelin by increasing ½ life to 30 minutes. 

      One oral pellet dissolved under your tongue in the morning x 12 weeks.

      CJC-1295 is a tetrasubstituted 29-amino acid Growth Hormone Releasing Hormone (GHRH) analog. It stimulates a release of HGH and IGF-1 without raising prolactin levels, leading to fat loss and increased protein synthesis thereby promoting CJC-1295 is a tetrasubstituted 29-amino acid Growth Hormone Releasing Hormone (GHRH) analog. It stimulates a release of HGH and IGF-1 without raising prolactin levels, leading to fat loss and increased protein synthesis thereby promoting the growth of muscle. Our CJC-1295 is compounded without DAC (Drug Affinity Complex) which provides a more effective GH spike resembling a normal physiologic release of GH.

      Ipamorelin Acetate is a Growth Hormone Releasing Peptide (GHRP) that assists in increasing the amount of growth hormone released. Ipamorelin is a pentapeptide composed of five amino acids and has a biological half-life of 2 hours after administration. It is widely known for being able to suppress somatostatin or Growth Hormone Inhibiting Hormone (GHIH). Using CJC-1295 in conjunction with Ipamorelin may be more effective in the production of growth hormone secretion, and in helping speed recovery time after an injury. Our CJC-1295 is compounded without DAC (Drug Affinity Complex) which provides a more effective GH spike resembling a normal physiologic release of GH.

      • Stimulate release and production of GH. 
      • Promotes muscle support and fat loss.

      DSIP – (Deep/Delta Sleep Inducing Peptide)

      Inject 100mcg Sub Q QHS 3 hours before bedtime

      DSIP is a naturally occurring, somnogenic nonapeptide with possible physiological functions impacting neuromodulation. DSIP is typically found in the brain and easily passes the blood-brain barrier. Studies indicate that DSIP and its analogs are best classified as peptide neuromodulators. DSIP has been shown to exhibit a pronounced stress-protective action and demonstrated a decrease in stress-induced metabolic disorders in both human and animal models. It is believed that DSIP works by modulating the activity of GABAergic, glutamatergic, and other neuronal systems.

      • Sleep promoting rather than a sedative. 
      • Helps with stages 3&4 of sleep.
      • Stimulates LH, Biggest surge of LH occurs during sleep

      Melanotan 2 – melanocortin Receptor Agonist

      Tanning Protocol: 200mcg SubQ QD x 1 week and then (after stabilizes) 100mcg SubQ 2x/week.

      Immune Support: 200mcg SubQ QD for 6-8 weeks total. Erectile Dysfunction:  Same as above 500-1000mcg produce more intense effects IN GENERAL.  [Benefit over PT141 – sexual stimulation gradually occurs over time and is more long-term).

      Melanotan II is an analog of the peptide hormone alpha-melanocyte-stimulating hormone (a-MSH) that induces skin tanning. Like its predecessor, Melanotan I, MT 2 plays a role in stimulating melanogenesis and thus provides a protective mechanism against UV rays since under its action’s melanocytes are able to increase the production and secretion of the hormone melanin. Scientists have also noticed that MT 2 had a positive effect on libido due to its aphrodisiac properties. Additionally, MT 2 exhibits a mild positive fat mobilizing effect. Melanotan I is an FDA-approved drug under the brand name Scenes. Scenes are most commonly used to treat patients that have an intolerance to light.

       

      • Cholinergic anti-inflammatory pathway.
      • Critical regulation of inflammation
      • Beneficial in neuro and cardioprotection
      • Autoimmunity

      GHK- Cu – naturally occurring Copper Peptide

      2mg (0.2ml – 20 units) Sub Q QD

      GHK-Cu is a naturally occurring copper complex that was first identified in human plasma but has since been found in multiple locations such as saliva and urine. Copper peptides are small, naturally occurring protein fragments that have a high affinity for copper ions, which evidence suggests are critical to normal body function. Clinical studies indicate that GHK-Cu has a variety of roles in the human body including, but not limited to, promoting activation of wound healing, attracting immune cells, antioxidant and anti-inflammatory effects, stimulating collagen and glycosaminoglycan synthesis in the skin fibroblasts, and promoting blood vessel growth. There have been some clinical evidence that has shown that GHK-Cu acts as a feedback signal generated after tissue injury and it may act as a potent protector of tissue and anti-inflammatory agent possibly by reducing the oxidative damage that occurs post tissue injury. Further, GHK-Cu has been found to be involved in signaling tissue remodeling by removing damaged/scarred tissue and generating healthy tissue. It has been shown in studies that GHK concentration decreases with age because the concentration of GHK-Cu in the body decreases with age which may result in an increase in inflammation, cancerous activity, and tissue destruction.

       

      • promotes wound healing -attract immune cells
      • antioxidant and anti-inflammatory effects
      • stimulation of collagen and glucosaminoglycan synthesis in skin fibroblasts
      • switches inflammatory process to the regenerative process

      Ibutamoren (MK-677)

      Oral – 10mg | 25mg QD.  No more than a 3-month cycle on and off for 3 months

      Ibutamoren is classified as a non-peptide growth hormone secretagogue and mimics the growth hormone stimulating action of ghrelin. Ibutamoren is potent, long-acting, and available through oral administration. Clinically, it has been demonstrated to increase the endogenous release of growth hormone (GH) as well as insulin-like growth factor 1 (IGF-1) without the adverse increase of prolactin or cortisol often seen with GHRPs. Additionally, increases in lean body mass can be achieved while lowering LDL cholesterol. Studies have shown Ibutamoren stimulates brain regions involved with metabolic action, such as the hypothalamus and the pituitary. Ibutamoren may be effective in increasing both muscle mass and bone mineral density, making it a promising therapy for the treatment of frailty and osteoporosis in the elderly.

      Thymosin Alpha 1 (thymic peptide – modulates innate immunity)

      1.5mg Q3 day.  Sick:  25 units BID x 3-5 days then 25 units QD x 3-5. IVP: 2ml 2x/week x 4 weeks OR 1-2ML IV for sickness

      Thymosin Alpha 1 (TA1) is a peptide originally isolated from thymic tissue and is a compound believed to be responsible for restoring immune function in thymectomized mice. Thymosin Alpha 1 has been shown to have a pleiotropic mechanism of action and affects multiple immune cell subsets that are involved in immune suppression. Studies have demonstrated improvements in immune system cell subsets and the potential of TA1 for the treatment of a range of diseases. Thus, Thymosin Alpha 1, due to the immune-stimulating effects exhibited by TA1, may have utility for the treatment of age or disease-related immune suppression. Improves tissue repair and healing. Improves hot defense to infection, Improves microcirculation, Reduces Inflammation. Improves tolerance to stress. Inhibits viral replication.

      Promotes T cell differentiation and maturation. Normalizes immune balance and response.

      Thymosin B-4 (repair/immune peptide)

      Sick:  25 units BID x 3-5 days then 25 units QD x 3-5.  IVP: 2ml 2x/week x 4 weeks

      Thymosin is a hormone secreted from the thymus. Its primary function is to stimulate the production of T cells, which are an important part of the immune system. Thymosin also assists in the development of B cells to plasma cells to produce antibodies. The predominant form of Thymosin, Thymosin Beta 4, is a member of a highly conserved family of actin monomer-sequestering proteins. In addition to its role as a major actin-sequestering molecule, Thymosin Beta 4 plays a role in tissue repair. Tß4 has been found to play an important role in the protection, regeneration, and remodeling of injured or damaged tissues. The gene for Tß4 has also been found to be one of the first to be upregulated after injuries. Thymosin Beta 4 is currently being trialed as a potential therapy for HIV, AIDS, and Influenza. Thymosin Beta 4 is most often prescribed for acute injury, surgical repair, and for senior athletes. It has most recently been shown to help regrow hair in addition to PRP.   Use with Thymosin Alpha 1 and BPC concurrently. DO NOT combine with BPC in the syringe

      Helps decrease scar tissue formation.   *Supports immunity, improves T cells *Neuroprotective *Anti-inflammatory. *Soft Tissue Repair/ulcers (pressure/venous), ischemic stroke

      You can not fix a problem you don’t understand. Advanced diagnostics is often necessary to get at the root cause. Once the root cause is identified, the solution becomes possible.

      Dr. Lisbeth Roy, D.O.

      Founder of Doctors Studio

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